| abstract |
Compounds of general formula (I), wherein each of m and n is independently 0 or 1; R and R, together with the carbon atom to which they are attached, form a heterocyclic ring containing one or two heteroatoms selected from oxygen, sulfur, -S (O) - and -S (O) -; Represents -CHF, -CF, -OCHF, -OCF, -SCHFor -SCF; X is a bond, -CH- or -ΝΗ-; And represents aryl, cycloalkyl, cycloalkenyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkenyl, optionally substituted by one or more identical or different substituents selected from R; and R represents hydrogen, amino, thioxo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, halogen, oxo, thio or hydroxy; or their pharmaceutically acceptable salts, hydrates or solvates are found to exhibit PDE4 inhibitory activity and may therefore be useful in the treatment of inflammatory diseases and disorders. |