| abstract |
The present invention relates to naphthalenecarboxamide derivatives, methods for their preparation and use. Their structure is shown in the form of formula (I), where the definitions of the groups R, R, R, R and Z are similar to those disclosed in the description. histone deacetylase and can be used to treat diseases associated with abnormal protein kinase activity or abnormal histone deacetylase activity, including inflammatory diseases, autoimmune diseases, cancer Nervous system diseases and neurodegenerative diseases, cardiovascular diseases, metabolic diseases, allergies, asthma or diseases related to hormonal disorders. |