http://rdf.ncbi.nlm.nih.gov/pubchem/patent/UA-100640-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c011cfdb5f40aeb932d4510bf12de543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49183a399f6c22479cbe30d2c6345c79 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate | 2011-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6606bad0befb0b658d2aaa266292b73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a36dff5f82f692bb8afdffb7a691045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a941c8c8c6f135195f16a87a0fb7da6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_320fa8cf65bf7baa7dd0938aae34a6a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38edfe64d6b74d449cfecf08f87c8771 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9154bdc91d28844ab755a124a916d62f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92099f72e45760dadccfa8dba58cd4ba |
| publicationDate | 2013-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | UA-100640-C2 |
| titleOfInvention | CALIQUE-CALIFORNIA CALIFORNIA |
| abstract | The invention relates to bioorganic chemistry, namely the synthesis of calixarene-1-hydroxymethylene-1,1-bisphosphonic acids of General formula, where R = H, X = OH, Y = OCHCHCH (compound A), R = CH (OH) [PO (OH)], X = OH, Y = ONSNSN (compound B), and the study of their properties as inhibitors of protein tyrosine phosphatase 1B. In the in vitro system, compounds (A) and (B) demonstrate inhibitory capacity for human RTP1B with ICV micromolar range and selectivity over other protein tyrosine phosphatases (TC-RTR, PTP-LAR). Compounds (A) and (B) are recommended as inhibitors of protein tyrosine phosphatase 1B and can be used in biology, pharmacology and medicine. [The invention relates to bioorganic chemistry, namely the synthesis of calixaren-1-hydroxymethylene-1,1-bisphosphonic acids of the general formula where R = H, X = OH, Y = OCHCHCH (compound A), R = CH (OH) [PO (OH)], X = OH, Y = OCHSCH (compound B), and study their properties as protein tyrosine phosphatase 1B inhibitors Compounds (A) and (B) are prepared by the sequential reaction of calix [4] arecarbonyl chlorides with trimethylsilyl phosphite and methanol. In the in vitro system, compounds (A) and (B) demonstrate inhibitory capacity for human RTP1B with IC in the micromolar range and selectivity over other protein tyrosine phosphatases (TC-RTP, PTP-LAR). Compounds (A) and (B) are recommended as inhibitors of protein tyrosine phosphatase 1B and can find applications in biology, pharmacology and medicine. |
| priorityDate | 2011-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.