| abstract |
The present invention relates to a heterocyclic compound represented by the general Formula (1): EMBED ISISServer, (1) in which R is a R5-Z1- group, etc., Z1 is a lower alkylene group, etc., and R5 is a group. represented by the general Formula: EMBED ISISServer, in which R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R represents a hydrogen atom; Y is CH or N; A1 means a heterocyclic ring selected from the group consisting of indole moieties, wherein the heterocyclic ring may have at least one substituent; T stands for -CO- group, etc .; R3 denotes a hydrogen atom, etc .; R4 means a lower alkyl group optionally substituted by one or more hydroxyl groups, etc .; R3 and R4, together with the nitrogen atom to which they are attached, can be bonded to each other and form a 5-10 membered saturated heterocyclic ring, and the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects on the inhibition of collagen production and / or the treatment of tumors. |