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filingDate 2019-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f67f0f87d2b88e70855b92b845549a1e
publicationDate 2021-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber TW-I736898-B
titleOfInvention Method for detecting unstable cell free dna and detecting apparatus thereof
abstract In an embodiment, the present invention relates to a technique in which small-sized cfDNA is detected, with ultrahigh sensitivity, from a liquid sample such as urine, cerebrospinal fluid, plasma, blood, pleural fluid, or body fluid, is concentrated and isolated, and then is analyzed for gene mutations without PCR. In particular, in a case where a positively charged nanostructure is used, capture and detection rates for cfDNA can be increased. A detection method according to an embodiment of the present invention does not require a PCR amplification reaction, which greatly shortens the time taken to obtain a result. In addition, since direct on-site analysis is possible without the need for specific equipment, it is expected that the present invention can be used as a point-of-care testing (POCT) capable of simultaneously searching multiple genes in a short period of time.
priorityDate 2018-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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