| abstract |
The present invention relates to the field of medicinal chemistry, in particular to a compound represented by formula (I), its preparation method and its medical use. In the compound represented by formula (I), the lactulose group is connected to the heteroatom in the aglycon (G) through a glycosidic bond, and the aglycon (G) is formed by removing a hydrogen atom from the heteroatom of the active drug molecule Group, and " "It means that the lactulose group is connected to the heteroatom in the aglycon (G) through an α-glycosidic bond or β-glycosidic bond. Pharmacokinetic tests have proved that the lactulose glycoside compound according to the present invention can pass through the gastrointestinal tract of mammals without being significantly absorbed by the gastrointestinal tract and not significantly hydrolyzed by the endogenous enzymes of the mammalian host, so the lactulose glycoside compound can reach the colon of mammal , Under the action of colonic flora, active drugs are released in the colon. The lactulose glycoside compound has a colon-localized drug release effect, and can be used for the prevention or treatment of intestinal diseases. |