| abstract |
The object of the present invention is to provide a freeze-dried preparation, which has an improved hepatocyte proliferation factor storage compared with traditional freeze-dried preparations. The concentration and stability of the hepatocyte proliferation factor are calculated according to the following formula (A). The present invention provides a freeze-dried preparation comprising (1) a hepatocyte proliferation factor, (2) trehalose, and (3) one or more compounds selected from the group consisting of arginine, Histidine, lysine, meglumine, glutamic acid, aspartic acid, proline, creatine, creatinine, trimethylolaminomethane, and pharmaceutically acceptable salts thereof. |