| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2876523df340f4a499e22ffcb5b3dfcb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1611
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4816
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-711 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-744
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-22 |
| filingDate |
2019-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4014c00a6cde878a58e28754dd8de885
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f66a0759b7cc623127556393e9dc13b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afe54316a0e09693375d7f20a81c02d3 |
| publicationDate |
2021-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-I727411-B |
| titleOfInvention |
Oral drug delivery system and method for fabricating thereof |
| abstract |
The invention relates to an oral drug delivery system including a biomimetic mineralized carrier and a yeast capsule. The biomimetic mineralized carrier includes a metal-organic framework and a biological macromolecule, in which the metal-organic framework has an internal space, and the biological macromolecule is coated in the internal space of the metal-organic nframework. The yeast capsule is loaded with the biomimetic mineralized carrier. Therefore, the oral drug delivery system can protect the biological macromolecule coated therein against pH changes and proteases in the gastrointestinal tract, and maintain activity of the biological macromolecule coated therein. In addition, the oral drug delivery system can target microfold cells of the intestinal tract, allowing the oral drug delivery system of the present invention to effectively transport across the intestinal epithelium in a membrane phagocytic mode to break through the mucosal barrier. |
| priorityDate |
2019-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |