| abstract |
The present invention provides anticancer prodrug nucleoside cyclic phosphate compounds based on liver specific delivery technology (Liver Specific Delivery (LSD)) and applications thereof. Specifically, the present invention provides compounds of formula I and their isomers Body, pharmaceutically acceptable salt, hydrate, solvate, and corresponding pharmaceutical composition. The invention also provides the application of the compound of the invention alone or in combination with other anticancer drugs in anticancer, especially in the treatment of liver cancer (HCC). |