| abstract |
The present invention discloses EGFR inhibitors, their preparation and the use thereof. Specially, the present invention relates to a formula (I), the derivates of 4-substituted-2-(N-(5-allyl amide) phenyl) amino) pyrimidine. The series of compounds with activity of inhibiting L858R EGFR mutant, T790M EGFR mutants and exon 19 deletion mutants can be used as treating diseases mediated by EGFR mutants alone or in part. For example, it can be widely used as prevention and treatment cancer, especially non-small cell lung cancer and is expected to develop a new generation EGFR inhibitor. |