| abstract |
The present invention provides a new class of imidazoline compounds and methods for preparing such compounds. Such compounds represented by formula (I) or pharmaceutically acceptable salts thereof have TLR7 and TLR8 agonistic activity, and can be used to treat cancer and prevent and treat viral infections. Where R is -(CH 2 ) m NR 1 R 2 , -(CH 2 ) n OR 3 or -(CH 2 ) q SR 4 ; R 1 and R 2 are independently selected from hydrogen and (C 1 -C 17 ) Alkyl, but R 1 and R 2 are not hydrogen at the same time; R 3 is (C 1 -C 17 ) alkyl; R 4 is (C 1 -C 17 ) alkyl; m, n and q are 1, 2 , 3, 4, 5, 6, 7, 8, 9 or 10. |