| abstract |
The present invention relates to an indolin-2-one derivative having the following formula: Where A is phenyl or a six-membered heteroaryl group containing one or two N atoms selected from: R 1 is S (O) 2 lower alkyl, S (O) 2 NR 4 R 5 , S (O) 2 cycloalkyl, S-lower alkyl or S (O) 2 -azetidine -1-yl; R 4 and R 5 are independently of each other hydrogen, lower alkyl or (CH 2 ) 2 OCH 3 ; or the group AR 1 may form together with two adjacent carbon atoms of the group A selected from Another fused ring: R 2 is hydrogen or cycloalkyl; R 3 is methyl or halogen; n is 1 or 2; X is N, N + O - or CH; --- the dashed line may be absent or -CH 2- ; And their pharmaceutically acceptable salts; racemic mixtures; or their corresponding enantiomers and / or optical isomers and / or their stereoisomers.n n n These compounds are useful in the treatment of diseases or conditions as described in the instructions. |