| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55fa76c9b7175910a5bffb3e26fb5b2a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-624
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-626
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2014-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84355f54cb46cfe2b38b70d014739f10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19ec906fef7f297ffbce111d129e93f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b87089649461e613779d8b5de820a132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a32a4b4e94d00c6ba6f5ad536583e82b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52b9d59657c44ae255d4306ae59e1a7c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7980b3eadf6b71cf5828b1064f253cfa |
| publicationDate |
2019-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-I675845-B |
| titleOfInvention |
Bispecific monovalent diabodies capable of binding gpA33 and CD3 and uses thereof |
| abstract |
The present invention relates to a bispecific monovalent diabody that includes two polypeptide chains and has at least one binding site specific to the epitope of CD3 and one binding site specific to the epitope of gpA33 (ie, "gpA33 x CD3 bispecific monovalent diabody "). The invention also relates to a bispecific monovalent diabody, which includes an immunoglobulin Fc domain ("bispecific monovalent Fc diabody") and a binding site consisting of three polypeptide chains and having at least one binding site specific for the epitope of gpA33 And a binding site specific for the CD3 epitope (ie, "gpA33 x CD3 bispecific monovalent Fc diabody"). Here, the bispecific monovalent diabody and the bispecific monovalent Fc diabody can bind gpA33 and CD3 simultaneously. The present invention relates to a pharmaceutical composition comprising such a bispecific monovalent diabody or such a bispecific monovalent Fc diabody. The invention further relates to methods of using such diabodies to treat cancer and other diseases and conditions. |
| priorityDate |
2013-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |