| abstract |
The invention provides compositions, compounds, and methods for regulating gene expression. In certain embodiments, the invention illustrates a composition, wherein the composition comprises antagonat. In some embodiments, the antigoNAT is an oligonucleotide comprising modified and unmodified sugar subunits, wherein the antigoNAT hybridizes to a natural antisense transcript. Certain embodiments of the present invention provide a method of modulating gene expression in a cell, comprising contacting the cell with antagonat. In some embodiments, the method includes forming a hybrid comprising the antigoNAT and a natural antisense transcript of the gene, wherein the hybrid spatially blocks the normal function of the natural antisense transcript. |