| abstract |
The present invention provides compositions and methods for treating autoimmune and allo-immune diseases and conditions. These autoimmune and allo-immune diseases and conditions include but are not limited to lupus, uveitis, encephalitis, rheumatoid Arthritis, multiple sclerosis, inflammatory bowel disease (IBD) (e.g. Crohn's disease, ulcerative colitis), optic neuritis, optic neuromyelitis, Sjögren's syndrome , Psoriasis, systemic scleroderma, ankylosing spondylitis, autoimmune hepatitis, graft vs host disease (GvHD), and organ transplant rejection. Such compositions that can be used to treat autoimmune diseases include pyrrolo-pyrazole PKC inhibitors. |