| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c509c10f7993bf4185abf29e4bf8d50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2cf7f3f36d20185ce15a2d1f04d5fdc1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1629
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1682
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1694
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1611
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1623
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F3-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 |
| filingDate |
2011-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe9429cd1f91381d44323fe2ac1e7e9f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08576bd47b4428b39c838e4eb55fcc71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ec86825f12ea38f3f5c5f5ae429611f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbc8429192488689b4b38a1d8ba92a9e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cec8725b1bfc0f0a35b60a7dbe1ea1c6 |
| publicationDate |
2019-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-I648261-B |
| titleOfInvention |
Melt-extruded solid dispersant containing apoptosis inducing agent |
| abstract |
A pro-apoptotic solid dispersant comprises a Bcl-2 family protein inhibitor compound of formula I as defined herein in a substantially non-crystalline form dispersed in a carrier comprising (a) a pharmaceutically acceptable water soluble polymer and b) In a solid matrix of a pharmaceutically acceptable surfactant. A method for preparing the solid dispersant comprises subjecting the compound of formula I, water-soluble polymer carrier and surfactant to high temperature to obtain an extrudable semi-solid mixture; extruding the semi-solid mixture; and cooling the resulting extrudate A solid matrix containing a polymer carrier and a surfactant and having the compound dispersed therein in a substantially non-crystalline form is obtained. The solid dispersant is suitable for oral administration to individuals in need to treat diseases characterized by one or more anti-apoptotic Bcl-2 family protein overexpression, such as cancer or immune or autoimmune diseases. |
| priorityDate |
2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |