| abstract |
The present invention relates to pyridine which can be used as an inhibitor of ATR protein kinase. Compound. The invention also relates to a pharmaceutically acceptable composition comprising a compound of the invention; a method of using the compound of the invention to treat various diseases, disorders and symptoms; a method of preparing a compound of the invention; an intermediate for preparing the compound of the invention; Methods for using the compound in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of novel kinase inhibitors.n n n The compounds of the invention have the formula I : n n n The variables are as defined herein. |