| abstract |
The present invention is based on the discovery that multiple IgG strains can promote Schwann cell maturation, differentiation, and myelin production. Methods are provided for treating non-idiopathic demyelinating peripheral neuropathy in mammals by administering multiple strains of IgG, wherein the neuropathy is not immune-mediated or infection-mediated. Types of demyelinating peripheral neuropathy that can be treated by the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathy. Alternatively, the composition of multiple strains of IgG can be directly applied to peripheral nerve cells to induce maturation, differentiation into a myelin forming state and myelin performance or to promote cell survival. |