| abstract |
The invention discloses a fused heterocyclic compound, a preparation method thereof, a pharmaceutical composition and an application thereof. The fused heterocyclic compound is represented by Formula I, Formula II or Formula III. A method for preparing the fused heterocyclic compound and / or a pharmaceutically acceptable salt thereof according to the present invention includes three synthetic routes. The present invention also provides a pharmaceutical composition of the fused heterocyclic compound, which contains the fused heterocyclic compound represented by Formula I, Formula II, and Formula III, and pharmaceutically acceptable salts, hydrates, and solvates thereof. , One or more of polymorphs and their prodrugs, and pharmaceutically acceptable carriers; and relates to the fused heterocyclic compound and / or pharmaceutical composition in the preparation of kinase inhibitors, and preparation for prevention and treatment and Application of Kinase-Related Diseases. The fused heterocyclic compound of the present invention has a selective inhibitory effect on PI3Kδ, and can be used for preparing drugs for preventing and treating cell proliferation diseases such as cancer, infection, inflammation, or autoimmune diseases. |