| abstract |
The present invention relates to a polymerase HBV mutant polypeptide, which comprises a mutant polymerase domain that functionally destroys polymerase activity; and a fusion protein comprising the polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and a expression vector for expressing the polymerase mutant polypeptide, and a composition which can be used to elicit an immune response against HBV, and aims to provide protective or therapeutic effects against HBV infection. . |