| abstract |
The present disclosure provides a compound having formula (I) or a pharmaceutically acceptable salt or solvate thereof. In formula (I), each of R1, R2 and R3 is independently hydrogen, amine, nitro, halogen, hydroxyl, C1-C6 alkoxy, carboxyl, C1-C6 alkoxycarbonyl, C1-C6 amine , C1-C6 aminocarbonyl, C1-C6 alkyl, C1-C6 branched alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclyl, aryl or heteroaryl, at least one of R1 and R3 Is amine. The disclosure also provides a linker-drug and ligand-drug conjugate comprising the compound. |