| abstract |
The present invention discloses compounds of formula (I) and / or their salts: n n n Where R 1 is -CH 2 CH 2 CF 3 ; R 2 is -CH 2 CH 2 CF 3 or -CH 2 CH 2 CH 2 CF 3 ; R 3 is H, -CH 3 or R x ; R 4 is H or R y; ring A system phenyl or pyridyl; and R x, R y, R a , R b, y and z system as defined herein. The present invention also discloses methods of using these compounds to inhibit Notch receptors, and pharmaceutical compositions containing these compounds. These compounds can be used to treat, prevent, or slow the progression of diseases or disorders (eg, cancer) in various medical fields; or prodrugs of these compounds. |