http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I610671-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adff709a8d25eaa0d3871ff46ff250eb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2011-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ecf5874b7b757deef6ee5b1e36af957 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_368f64f46eb505f828fe8e9e53252d94 |
| publicationDate | 2018-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-I610671-B |
| titleOfInvention | Intravenous preparation of coenzyme Q10 (CoQ10) and use method thereof |
| abstract | Disclosed herein are formulations suitable for parenteral administration of certain hydrophobic active agents such as Coenzyme Q10. Also provided herein are methods of their preparation and methods of using them to treat tumor disorders. The formulations include an aqueous solution; a hydrophobic active agent dispersed to form particles of a colloidal nano-dispersion; and at least one of a dispersion stabilizer and a conditioning effect reducing agent, wherein the active agent is a colloidal nano-dispersion Disperse into nano-dispersed particles with an average size of less than 200 nm. A method for preparing parenteral formulations includes dispersing a hydrophobic active agent by high-pressure homogenization in the following manner: (1) adding a hydrophobic active agent to a 65 ° C water bath and mixing to form a hydrophobic active agent / water mixture; (2) adding the hydrophobic active agent Add a dispersion stabilizer to the active agent / water mixture and mix at 65 ° C to form a hydrophobic active agent / water / stabilizer mixture; (3) add a conditioning effect reducing agent to form a hydrophobic active agent / water / stabilizer / lowering agent mixture; (4) preheat the microjet homogenizer to 65 ° C; and (5) process by mixing the hydrophobic active agent / water / stabilizer / reducing agent mixture in the microjet homogenizer at 65 ° C to form an average particle Hydrophobic active agent colloidal nano dispersion with diameter less than 200nm. Also provided herein are methods of treating a tumor condition by administering a formulation described herein to an individual to treat or prevent the tumor condition. |
| priorityDate | 2010-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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