| abstract |
The present invention provides antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derived antibodies, and combinations thereof with cytotoxic agents that specifically bind to CD38, which are capable of undergoing apoptosis, antibody dependence, Sexual cell-mediated cytotoxicity (ADCC) and / or complement-dependent cytotoxicity (CDC) kills CD38 + cells. These antibodies and fragments thereof can be used to treat tumors expressing CD38 protein, such as multiple myeloma, chronic lymphocytic leukemia, chronic myelogenous leukemia, acute myeloid leukemia, or acute lymphocytic leukemia; or to treat autoimmunity and inflammation Diseases such as systemic lupus, rheumatoid arthritis, multiple sclerosis, erythema and asthma. These derived antibodies can be used to diagnose and image tumors with increased CD38 expression. Also provided are a cytotoxic conjugate comprising a cytotoxic agent and a cytotoxic agent, a therapeutic composition comprising the conjugate, a method for inhibiting cell growth and treating a disease using the conjugate, and a kit comprising the cytotoxic conjugate. In particular, the cell-binding agent is a monoclonal antibody that recognizes and binds CD38 protein and an epitope-binding fragment thereof. |