| abstract |
A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof [In the formula, A represents a C3 to C12 cycloalkyl group which may be substituted by 1 to 3 selected from a fluoro group, a hydroxyl group, a C1 to C6 alkyl group, and the like, and R 1 , R 2, and R 3 each independently represent a hydrogen atom. , Fluoro or C1-C6 alkyl, R 4 represents a hydrogen atom or a prodrug group, and Y represents -CH 2 -CHR 5 -CH 2 -NHR 6 (where R 5 represents a hydrogen atom, C1-C6 alkyl, or C1 ~ C6 alkoxy, R 6 represents a hydrogen atom or a prodrug group.) And the like. ], Has TAFIa enzyme inhibitory activity, and is used as a therapeutic agent for myocardial infarction, angina pectoris, acute coronary insufficiency syndrome, cerebral infarction, deep venous thrombosis, pulmonary embolism and the like. |