| abstract |
The present invention provides antineoplastic compounds of the formula, and antineoplastic methods. A compound of formula I, where -X=Y- is formula, R1 is selected from the group consisting of halo, C1-C6 alkyl, and CF3; R2 is selected from the group consisting of halo, -NO2, C1-C6 alkyl, and CF3; R3 is H, C1-C6 alkyl, C1-C5 alkoxy, C1-C6 alkylthio, or halo; R4 is selected from the group consisting of H, halo, C1-C4 alkoxy, C1-C6 alkyl, -COO(C1-C6 alkyl), C1-C6 alkyl optionally substituted with Cl-C4 alkoxy, cyano, C1-C6 alkylthio, CF3, S-phenyl, and pyridinyl; R5 is halo, C1-C6 alkyl, or C1-C4 alkoxy; or a pharmaceutically acceptable base addition salt thereof. |