| abstract |
Compounds of the formula I, in which R1 to R9 have the meanings given in the claims are exceptionally suitable as antihypertensives, for reducing or preventing ischemia-induced damage, as medicaments for surgical intervention for the treatment of ischemias of the nervous system, of stroke and of cerebral edema, of shock, of impaired respiratory drive, for the treatment of snoring, as laxative, as agent against ectoparasites, to prevent the formation of gallstones, as antiatherosclerotics, agents against late complications of diabetes, cancers, fibrotic disorders, endothelial dysfunction, organ hypertrophies and hyperplasias. They are inhibitors of the cellular sodium-proton antiporter. They influence serum lipoproteins and can therefore be used for the prophylaxis and for the regression of atherosclerotic lesions. |