http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I281395-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bdd619b8a2cc2f110b9ee4dc8d896a17 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C247-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-04 |
| filingDate | 2000-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27b22d5567f197a7c98eb5dadb6c2ec1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdf9a75e7b6b4ee6a3a6ea04d076b34d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4af4fa84ebfb89c6342add44ce70e82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_392d6a7c05e3ecef56b85df0b3b44743 |
| publicationDate | 2007-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-I281395-B |
| titleOfInvention | Hydroxyeicosatetraenoic acid analogs, the composition thereof and use thereof in the manufacture of a medicament for treating dry eye and other disorders requiring the wetting of the eye in mammals |
| abstract | Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders are disclosed. A pharmaceutical composition for the treatment of dry eye and other disorders requiring the wetting of the eye comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of one or more compounds of the following formula I, wherein: R1 is CO2R, CONR2R3, CH2OR4, CH2NR5R6, CH2N3, CH2Hal, CH2NO2, CH2SR20, COSR21, or 2,3,4,5-tetrazol-1-yl, where: R is H, C1-6 alkyl, C3-8 cycloalkyl, phenyl, benzyl, or CO2R forms a salt of the form CO2-M+, where M+ is Li+, Na+, Na+, or NH4+; R2 and R3 are the same or different and are H, C1-6 alkyl, C3-8 cycloalkyl, phenyl, or benzyl; R5 and R6 are the same or different and are H, C1-6 alkyl, C3-8 cycloalkyl, phenyl, or benzyl, or are C(O)R22, where R22 is H, C1-6 alkyl, C3-8 cycloalkyl, phenyl, or benzyl; R4 is H, C1-6 alkyl, C3-8 cycloalkyl, phenyl, or benzyl, or are C(O)R22, where R22 is H, C1-6 alkyl, C3-8 cycloalkyl, phenyl, or benzyl; Hal is F, Cl, Br, or I; R20 is H, alkyl or acyl; R21 is H, C1-6 alkyl, C3-8 cycloalkyl, phenyl, or benzyl; K is CH2CH2, CH=CH, or C=C; B and D are the same or different and are CH2CH2, CH=CH, or C=C; and Y is C(O) (i.e. a carbonyl group) or Y is formula, wherein R9 is H, C1-6 alkyl, C3-8 cycloalkyl, phenyl, or benzyl; or is C(O)R22, where R22 is H, C1-6 alkyl, C3-8 cycloalkyl, phenyl, or benzyl. |
| priorityDate | 1999-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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