http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I280239-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-465 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82 |
| filingDate | 2004-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91f5ba037dbb45eec94095f935929264 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89f8b4f919ac3dbba63e9f52ec53c3fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fd56820d460019ff0a1ebbdf96c4aba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b501a1a5c5f0fb7dce15ea9be215996 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51c3ce5b8bf993f926892cdc399a4311 |
| publicationDate | 2007-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-I280239-B |
| titleOfInvention | Process for preparation of pyridine derivatives |
| abstract | The present invention relates to a process for the manufacture of compounds of general formula wherein the substituents are as described in claim I characterized in that it comprises the steps of (a) reacting a compound of formula (X), with a compound of formula (XIII), to a compound of formula (XIVa)/(XIV); (b) converting the OH/=O functional group of compounds of formula XIV/XIVa into a leaving group P with a reagent containing a leaving group, selected from the group comprising POCl3, PBr3, Mel or (F3CS02)2O to form a compound of formula (XV), wherein P is halogen or trifluoromethanesulfonate; (c) substituting the leaving group P by R2 with HR2 to form a compound of formula (XVI); (d) hydrolyzing the nitrile function in an acidic medium comprising H2SO4, HCl or acetic acid, to a compound of formula (I). The compounds of formula I are valuable intermediates for the manufacture of therapeutically active compounds which have NK-I antagonist activity. |
| priorityDate | 2003-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 232.