| abstract |
Compounds of formula (I): [wherein: A represents a pyrrole ring; R1 represents a phenyl group optionally substituted with halogen or CF3; R2 represents a pyridyl group optionally substituted with C1-4 alkylamino or phenyl-C1-4 alkylamino, or a pyrimidinyl group substituted with C1-4 alkylamino; R3 represents a group of the formula -X-R4, wherein: X is single bonds or straight or branched alkylene groups having from 1 to 6 carbon atoms; R4 is selected from the group consisting of cycloalkyl groups having 3-6 carbon atoms which are substituted with an amino group, heterocyclyl groups having at least one nitrogen atom in which said heterocyclyl groups may optionally be substituted with at least one substituent selected from the group consisting of hydroxy groups, C1-4 alkyl groups which may optionally be substituted with a phenyl group or nitro group, or C2-4 alkeny group, wherein said heterocyclyl groups are 4- to 12-membered non-aromatic heterocyclyl groups containing one nitrogen atom and optionally containing one further hetero-atom selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms, heteroaryl groups having at least one nitrogen atom, said groups optionally being substituted with at least one halogen atom, wherein said heteroaryl groups are 5- to 7-membered aromatic heterocyclyl groups containing one or two nitrogen atoms; provided that said substituents R1 and R3 are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R2 is bonded] have excellent inhibitory activity against the production of inflammatory cytokines. |