| abstract |
2-[3-(4-Fluoro-3-(pyridin-3-yl)phenyl)imidazo[1,2-alpha]pyrimidin-7-yl]propan-2-ol and 4,2'-difluoro-5'-(7-trifluoromethylimidazo[1,2-alpha]pyrimidin-3-yl)biphenyl-2-carbonitrile, and pharmaceutically acceptable salts thereof, are selective ligands for GABAA receptors, in particular having good affinity for the alpha2 and/or alpha3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders. |