| abstract |
The invention relates to novel intermediates for use in the preparation of 9,11-expoxy steroids, which include those for formula, D, E, F, 211, 210, 209, 208, 207, 206, 205, 204 and 203 as defined in the claims. A compound corresponding to formula D: wherein -A-A- represents the group -CHR4-CHR5- or -CR4=CR5-; R3 is selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano and aryloxy; R17 is C1 to C4 alkyl; and -B-B- represents the group -CHR6-CHR7- or an alpha- or beta- oriented group: where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, but the compound of the following formula is excluded: wherein -A-A- represents the group -CH2-CH2- or -CH=CH-; and R17 is C1 to C4 alkyl. |