| abstract |
A subject-matter of the present invention is compounds of formula, and their preparation and the pharmaceutical compositions comprising them. These compounds are agonists for CB2 cannabinoid receptors. Compound of formula, in which: Ar represents: (a) a phenyl mono-, di- or trisubstituted by one or more groups chosen from: a halogen atom, a (C1-C4)alkyl, a trifluoromethyl, an ammo, a nitro, a hydroxyl a (C1-C4)alkoxy, a (C1-C4)alkylsulphanyl or a (C1-C4)alkylsulphonyl; (b) a naphthyl which is unsubstituted or substituted once or twice by a halogen atom, a (C1-C4)alkyl or a trifluoromethyl; A represents a C2-C6 alkylene radical; Y represents a group chosen from SR4, SOR4, SO2R4, SO2NR5R6, N(R7)SO2R4,OR4 or NR7SO2NR5R6; R1, R3 and R'3 represent, each independently of one another, hydrogen a hydroxyl, a halogen atom, a (C1-C4)alkyl, a trifluoromethyl or a (C1-C4)alkoxy; R2 represents hydrogen or a (C1-C4)alkyl; R4 represents a (C1-C4)alkyl or a trifluoromethyl; R5 and R6 each independently represent hydrogen or a (C1-C4)alkyl; R7 represents hydrogen or a (C1-C4)alkyl; and its optional salts and/or its solvates. |