| abstract |
The present invention relates to compounds of the formula (I). These compounds are useful as psychotherapeutic agents. A compound of the formula (I) wherein R3, R4, and Z are selected, independently, from hydrogen, halo (e.g., chloro, fluoro, bromo or iodo), (C1-C4) alkyl optionally, substituted with from one to three fluorine atoms, (C1-C4) alkoxy optionally substituted with from one to three fluorine atoms, and (C1-C4)alkoxy-(C1-C4)alkyl wherein each of the alkyl morieties may optionally be substituted with from one to three fluorine atoms; W is -CH2-O-(C1-C6)alkyl wherein the alkyl moiety can be straight or branched, or W is -CH2NR1R2 wherein R1 and R2 are independently selected from hyidrogen, straight or branched (C1-C6)alkyl and (C3-C7)cycloalkyl; or R1 and R2 together with the nitrogen to which they are attached, form an azetidine, pyrrolidine, morpholine, piperazine, azabicyclo[3.2.2]nonane or octahydro-isoindol optionally substituted with one or two groups selected from hyidroxyl, (C1-C4) straight or branched alkyl and (C1-C4) straight or branched alkoxyi-(C1-C4) straight or branched alkyl, with the proviso that in any ring formed by NR1R2 there can be no hydroxyl or alkoxymethyl moiety bonded directly to any nitrogen atom; and the pharmaceutically acceptable salts of such compounds. |