| abstract |
The novel compounds of formula (I) (the meanings of A and R1 to R4 are given in the description) may be produced by conventional methods and therapeutically used as, for example, LTB4 antagonists. A compound of new substituted Benzamidine of formula (I), wherein A is a group of -X1-CmH2m-X2- (II) or formula (III), X1 is O; X2 is O or formula (IV), X3 is -X-CnH2n- (n=1 or 2, X=O); X4 is -CnH2n-X- (n=1 or 2, X=O); R1 is OH, COphenyl, COpyridyl, COO-C1-C6-alkyl, COO-C1-C6-alkyl-phenyl, or COO-menthyl; R2 is C1-C6-alkyl or CR5R6-phenyl, wherein phenyl is unsubstituted or substituted by OH; R3 is H or C1-C6-alkoxy; R4 is H; R5 is C1-C3-alkyl; R6 is C1-C3-alkyl; R8 and R9 are H. |