| abstract |
An object of the invention is to improve the solubility of a glycosphingolipid by preparing a freeze-dried composition and a manufacture method thereof; the freeze-dried composition comprises an alpha-glycosylceramide represented by general formula (A) or a salt thereof, a polyoxysorbitan/aliphatic anhydride ester, and a disaccharide or monosaccharide and preferably further contains deoxycholic acid or histidine. On said formula, R1 is H or OH; X is an integer of 7 to 25; R2 is -CH2(CH2)YCH3, -CH(OH)(CH2)YCH3, -CH(OH)(CH2)YCH(CH3)2, -CH=CH(CH2)YCH3, or -CH(OH)(CH2)YCH(CH3)CH2CH3 (where Y is an integer of 5 to 17); one of R3 and R4 is H and the other is H, OH, NH2, or NHCOCH3; one of R5 and R6 is H and the other is OH; one of R7 and R8 is H and the other is OH; and R9 is H, CH3, or CH2OH. |