http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-548257-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_09fc02a407043ca0a10e2dbe5fcb6159 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- |
| filingDate | 2001-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a67980400dfa17263379c76d34e9db9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_957fd2611d542a1a969f7d962b183d8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42124ab1d61ba32d0f3494775c0c9c16 |
| publicationDate | 2003-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-548257-B |
| titleOfInvention | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| abstract | The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed. Such compounds may optionally act as intermediates for making other compounds, e.g., hydrogenation of unsaturated groups on the substituent. |
| priorityDate | 1999-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.