| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_04b97f65228ff8f6aaf166338eee8105 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-904
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-915
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-906 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2009 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 |
| filingDate |
1996-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fb6920289ac49048a949abfc45ab7c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76fe210dc6a74f6fe0acf5a533aa0570
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67b238d8270f266ceb6dc1d79433f79c |
| publicationDate |
2003-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-518237-B |
| titleOfInvention |
Directly compressible high load acetaminophen formulations |
| abstract |
Direct compressed solid pharmaceutical dosage forms containing: (a) from about 40 to about 95% by weight acetaminophen; (b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and (c) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e., up to 80% or greater) amounts of acetaminophen based on the weight of the total tablet. |
| priorityDate |
1995-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |