abstract |
Compounds of formula (I), processes for their preparation and their use as CNS agents are disclosed: in which Ra is a group of formula (i), in which P1 is phenyl, naphthyl, quinolinyl, or tetrahydroisoquinolinyl; R1 and R2 are independently hydrogen, halogen, C1-6alkyl, cyano, C1-6alkoxy-carbonylamino; a is 1 or 2; or Ra is a group of formula (ii) wherein P2 and P3 are independently phenyl, naphthyl, thienyl, furyl, imidazolyl, oxazolyl, pyrazolyl, thiazolyl, oxadiazolyl, pyrimidyl, pyridazinyl, pyrazinyl, pyridyl, piperidinyl, quinolinyl, isoquinolmyl, or tetrahydroisoquinolinyl; A is a bond or oxygen, -CH2-CH2-, or NR4 where R4 is hydrogen or C1-6alkyl; R1, R2, R3 are independently hydrogen, halogen, C1-6alkyl, C1-6alkanoyl, or cyano; Y is -NH- or -CH2-; W is -CH=CH- or -(CH2)t-, where t is 2 or 3; Rb is hydrogen, halogen, C1-6alkyl, trifluoromethyl, C1-6alkoxy, or C2-6alkenyl; Rc is hydrogen or C1-6alkyl. |