| abstract |
The present invention refers to compounds of general formula (I), wherein: X1, X2, X3, X4 are -CONR-, R is H, f is 1, m is 0, R1 is the lateral chain of tryptophan; R2 is the lateral chain of phenylalanine possibly substituted with up to two residues chosen among: chlorine, fluorine, CF3, OH, CN; or a group 3-pyridyl-methyl; or a group 4-pyridyl-methyl; R3 is benzyl. R5 is H, R4 is a group chosen among: NR8R9, where R8 is H or methyl; and R9 is a methanesulfonyl, tosyl, 4-tetrahydropyranyl, 4-tetrahydrothiopyranyl, 1-oxo-tetrahydrothiopyran-4-yl, 1,1-dioxo-tetrahydrothiopyran-4-yl N-methyl-4-piperidinyl, N-metansulfonyl-4-piperidinyl, N-aminosulfonyl-4-piperidinyl, or a group (CH2)g-R10 where g is 1,2, and R10 is chosen among morpholine, furan, CN; or R8 and R9 together with the N atom to which they are linked represent; N-methyl-piperaziniyl, N-acetyl-piperazinyl, piperazinyl, N-methanesulfonyl-piperazinyl -N(R11)CO(CH2)h-R12 wherein R11 is H, h is 0 or 1, and R12 is chosen among: 1-tetrazolyl, 5-mercapto-tetrazol-1-yl, 1-triazolyl, furanyl, thiophenyl, morpholine, 4-hydroxy-piperidine, 4-cartoxyamido-piperidine, 3-hydroxy-pyrrolidine, 2-hydroxymethylpyrrolidine, 4-methyl-piperazine, 4-aminosulfonyl-piperazine, 1-oxo-thiomorpholine, 4-hydroxy-cyclohexan-1-yl-amino -COR13 wherein R13 is a group chosen among morpholine and 3 acyl o 4-(hydroxyethyloxyethyl)-piperazine, as enantiomers or mixture of diastereoisomers, and their pharmaceutically accepatble salts. |