http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-491856-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0efa077d881a96aeb1e29b21ef1bbb58 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0205 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K4-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 1997-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5ccfafbfd32b3054d65d34487e320b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24e0e362c40cd0e06ae38ff019ff9af0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfdb7f087fcc2e2107663940f3d74926 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91c584d0be50b577256398f9fcb266f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43e406ef7af93fcdfeb64b6960b5ecb1 |
| publicationDate | 2002-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-491856-B |
| titleOfInvention | Novel tetrapeptides as antitumor agents |
| abstract | The present invention provides anti-tumor peptides of formula I, A-B-NR3-CHD-CH(OCH3)-CH2CO-E-K, and the acid salts thereof. A is an amino acid residue selected from the group consisting of N-methyl-D-prolyl, N-methyl-D-homoprolyl and N,N-dimethyl-2-ethylphenylglycyl, or an amino acid residue, of the formula R1R2N-CHX-CO, wherein R1 is a methyl group or an ethyl group, R2 is a hydrogen atom, a methyl group or an ethyl group, and X is an alkyl group. B is an amino acid residue selected from the group consisting of valyl, isoleucyl, leucyl, and 2-t-butylglycyl. R3 is a hydrogen atom or a methyl group. D is a normal or branched C2-C5-alkyl group. E is an amino acid residue selected from the group consisting of prolyl, homoprolyl, 5-methylprolyl, and phenylalanyl, or E is a residue derived from an amino acid comprising a pyrrolidine group. K is an alkoxy group or an amino group. An additional embodiment of the present invention is a method for treating a malignancy in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound or compounds of formula I in a pharmaceutically acceptable composition. |
| priorityDate | 1996-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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