| abstract |
A class of substituted 1,2,4-triazolo[4,3-b] pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkyoxy moiety at the 6-position, are selective ligands for GABA-A receptors, in particular having high affinity for the Α2 and/or Α3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions. |