| abstract |
A compound of the formula (I) or a salt thereof, wherein R1 is an amino group or a group represented by the formula, wherein R7 is an amino group which may be substituted with a Α-L-amino acid residue which may be substituted with a Α-L-amino acid residue, and R8 represents a C1-6 alkyl group, a C2-6 alkeyl group and a-cyclopropyl-C1-3 alkyl group; R2 represents carboxy, (C1-6 alkoxy)carbonyl, phenoxycarbonyl, (phenyl1-C1-4 alkyloxy)carbonyl, diphenylmethyloxycarbonyl, pivaloyloxymethoxycarbonyl, carbonyl substituted with an amino acid residue and carbamoyl; R3, R4, R5 and R6 each represent hydroxy or C1-16 alkanoyloxy group, or two of them are combined into a cyclic group, wherein R is C1-4 alkyl; and Q is phenyl which is unsubstituted or may be substituted by C1-4 alkyl; or a salt thereof. The compound (I) possesses anti-Helicobacter pylori activity, and useful in the prevention or treatment of various disease associated with Helicobacter bacteria, such as duodenal ulcer, gastric ulcer, chronic gastritis, and cancer of the stomach. |