| abstract |
A compound which is a cysteine protease inhibitor of formula 1, in which: n is 0 to 2; A-B represents a linkage of -C(O)NH-; X represents a bond, methylene or the linkage -CH2CH(R4)-, wherein R4 is hydrogen or C1-4 alkyl; Y is -NH-; Z is -C(R6)(R7)- wherein R6 is hydrogen or methyl and R7 is as defined below; Z1 is -C(R5)(R8)-, wherein R6 is hydrogen or methyl and R8 is as defined below; R1 is morpholinecarbonyl, phenyl-C1-6 alkyl-carbonyl, or C1-6 alkyl-carbonyl wherein the C1-6 alkyl is optionally substituted with carboxyl group or C1-4 alkyl ester of the carboxyl group; R7 is hydrogen, C1-6 alkyl or phenyl- or napthyl-C1-6-alkyl optionally substituted with hydroxyl on the phenyl or rapthyl moiety, R8 is hydrogen, phenyl-C1-6 alkyl, or carboxy-C1-6 alkyl; and R2 is hydrogen, C1-6 alkyl optionally substituted with one or more radicals selected from halo, phenyl, napthyl, phenyl-C1-6 alkyl, or napthyl-C1-6-alkyl; and the pharmaceutically acceptable salts, individual isomers and mixtures of isomers thereof. |