abstract |
Amyloid aggregation in animals is inhibited by administering a 9-acridinone compound of the formula, wherein: R1 and R2 are hydrogen, halo, nitro, amino, hydroxy, trifluoromethyl, alkyl, alkoxy, and alkylthio; R3 is hydrogen or alkyl; and R4 is -alkylene-NR5R6. The compounds are especially useful in preventing and treating Alzheimer's disease. |