| abstract |
Compounds of the formula (I), as well as their pharmaceutically acceptable salts, and pharmaceutical compositions comprising the novel compounds. The novel compounds of the formula (I) are useful in the management of pain. A compound of formula (I), wherein G is a nitrogen atom; A is selected from: (i) phenyl substituted by -COOCH3, -CN or -COCH3; (ii) naphthly; (iii) R1 is selected from the group consisting of: H; C2-C6 alkenyl; and (C1-C6 alkyl)1-B wherein B is phenyl or cyclopropylmethyl; R2 is selected from the group consisting of H and CH3; R9, R10, R13, R14, R17 and R18 are selected from the group consisting of H, a branched or straight C1-C6 alkyl and C2-C6 alkenyl; B is a phenyl unsubstituted or substituted by one to two substituents selected from the group consisting of C1-4 alkoxy, halogen, C1-4alkyl and Α-C1-6 alkylaminocarbonyl, naphthyl or C5-6 cycloalkyl; R3, R4, R5 and R6 are each independently selected from the group consisting of: H and a C1-C3 alkyl; as well as pharmaceutically acceptable salts of the compounds and isomers, other than positional isomers, thereof; with the proviso that when B is an unsubstituted phenyl, neither R13 nor R14 can be H or CH3. |