http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-450975-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-56 |
| filingDate | 1997-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5c5bc37cda3299fd14feffa19fa5232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6e31fc957592a75cddb1d1fda6b657d |
| publicationDate | 2001-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-450975-B |
| titleOfInvention | A process for preparing certain AZA cyclohexapeptides |
| abstract | A process for preparing aza cyclohexapeptide compounds of the formula, wherein R1 is CH2CH2NH2 or CH2CONH2; RI is C9-C21 alkyl, C9-C21 alkenyl, C1-C10 alkoxyphenyl, C1-C10 alkoxynaphthyl, or C1-C10 alkoxyterphenyl; RII is H, C1-C4 alkyl, C3-C4 alkenyl, (CH2)2-4OH, or (CH2)2-4NRIVRV; RIII is H, C1-C4 alkyl C3-C4 alkenyl, (CH2)2-4OH, (CH2)2-4NRIVRV, or RII and RIII taken together are (CH2)4, (CH2)5, (CH2)20(CH2)2 or (CH2)2NH(CH2)2; RIV is H or Cl-C4 alkyl; RV is H or Cl-C4 alkyl; Q is N or O; or pharmaceutically acceptable acid addition salts thereof which comprises the steps of (a) reacting compound II of the formula, with phenylboronic acid, p-methoxyphenylboronic acid or methaneboronic acid to afford compound Tn of the formula, (b) which is subsequently reduced to the amine and hydrolyzed to afford compound IV of the formula, (c) which is reacted with thiophenol in a suitable solvent to afford compound V of the formula; which is stereoselectively converted to compound I by displacement of the phenylthio group. |
| priorityDate | 1996-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 109.