| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-53 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C313-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-12 |
| filingDate |
1994-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17db1dc4fb6586f71c887af38eda3470
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a5bb722e125a9a6deee2cccc7cdc3c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b367a2748e2cae3e2bb7e9d747a35d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39206be44963c13e7196d57e8c5d6b2e |
| publicationDate |
2001-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-448160-B |
| titleOfInvention |
Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
| abstract |
The present invention relates to a process for the preparation of the sodium salt of a compound of formula (I), wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: generating the dilithium dianion of 1-(mercaptomethyl) cyclopropancacetic acid; reacting said dianion with a compound of formula (II), wherein HET is as defined above and L is arylsulfonyl or alkylsulfonyl; and converting the resultant compound of formula I into the corresponding dicyclohexylamine salt; isolating the crystalline dicyclohexylamine salt of the compound of formula I; treating the dicyclohexylamine salt of the compound of formula I, in a mixture of organic solvent and water, with an acid; treating the product thus obtained with a source of sodium ion; and crystallizing the resultant sodium salt from toluene: acetonitrile. The invention further provides the dicyclohexylamine salt of a compound of formula (I). |
| priorityDate |
1993-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |