http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-427975-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-02 |
| filingDate | 1995-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ea6a7969865e2730745a1f4f613dbc5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d59569b546900c44db9faa81fdc33d46 |
| publicationDate | 2001-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-427975-B |
| titleOfInvention | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents |
| abstract | The present invention provides a novel process for preparing novel compounds of formula I, wherein R1 and R2 each are independently C1-C4 alkyl, or combine to form piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; and n is 2 or 3; or a pharmaceutically acceptable salt thereof, comprising (a) reacting a haloalkyl amine of formula III, wherein X is a halogen; and R1, R2, and n are as defined above, with a compound of formula IV, wherein R is C1-C6 alkyl, in the presence of an alkyl acetate solvent and a base; (b) extracting the reaction product of step (a) with an aqueous acid; and (c) cleaving the ester of the reaction product from step (b) to form an acid. The present invention further provides a novel process for preparing compounds of formula V, wherein R1 and R2 each are independently C1-C4 alkyl, or combine to form piperidinyl, pyrrolidino, methylpyrrolidino, dimethylpyrrolidinyl, morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; R3 and R4 each are H or a hydroxy protecting group; and n is 2 or 3; or a pharmaceutically acceptable salt thereof, comprising (a) reacting a haloalkyl amine of formula III, wherein X is a halogen; and R1, R2, and n are as defined above, with a compound of formula IV, wherein R is C1-C6 alkyl, in the presence of an alkyl acetate solvent and a base; (b) extracting the reaction product from step (a) with an aqueous acid; (c) cleaving the ester of the reaction product from step (b) to form an acid; (d) reacting the extracted product from step (c) with a compound of formula V, wherein R3 and R4 are as defined above, or a pharmaceutically acceptable salt thereof; (e) optionally removing the R3 and R4 hydroxy protecting groups of the reaction product form step (d); and (f) optionally forming a salt of the reaction product from either steps (d) or setp (e). |
| priorityDate | 1994-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.