| abstract |
The present invention descloses a parenteral pharmaceutical composition of a human insulin analog complex, for use in the treatment of diabetes, which complex comprises: six molecules of human insulin wherein Pro at position B28 is substituted with Asp, Lys, Leu, Val, or Ala; and Lys at position B29 is Lys or substituted with Pro; des(B28-B30)-human insulin; or des(B27)-human insulin; two zinc ions; and at least three molecules of a phenolic derivative selected from the group consisting of m-cresol, phenol, or a mixture of m-cresol and phenol; such that the composition is of a zinc-phenol hexamer complex which has a faster rate of absorption than human insulin, the composition being equally stable when compared to human insulin against chemical degradation. |